I posted a comment on the Shtetl blog, rejecting (once again) the many worlds interpretation (mwi); it is supposed to solve the "measurement problem" of quantum theory, so let us first consider a simple experiment with 2 possible outcomes.
The main mwi assumption is that after the measurement both outcomes are realized and subsequently two macroscopically different configurations M1 and M2 exist in some (decohered) superposition.
However, we can make the differences between M1 and M2 arbitrarily large and therefore gravitation cannot be ignored. M1 and M2 will in general be associated with two different space-time geometries and so far we do not have a consistent framework to deal with such a superposition.
In a few cases it has been tried to describe such an evolution but the conclusions are not in favor of mwi.
And how would the branching of space-time(s) work if the measurement is spread out over spacelike events, e.g. in an EPR-type experiment?
This gets worse if one considers a realistic experiment with a continuum of possible outcomes, e.g. the radioactive decay of a Pu atom, which can happen at any point of the continuous time parameter t. Assuming that this decay gets amplified with a Geiger counter to different macroscopic configurations, how would one describe the superposition of the associated continuum of space-time geometries?
The Copenhagen interpretation does not have this problem, because it only deals with one outcome and in general one can "reduce" the wave function before a superposition of spacetime geometries needs to be considered.
A mwi proponent may argue that this issue can be postponed until we have a consistent theory of quantum gravity and simply consider a Newtonian fixed background (or a flat Minkowski background). But if one (implicitly) allows the existence of Newtonian clocks, then why not the classical observer of Copenhagen?
In addition one has to face the well known problem of the Born probabilities, the preferred basis problem, the question of what it takes to be a world and others, discussed previously on this blog.
In other words, the mwi so far creates more problems than it solves.